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本实验应用放射免疫测定法，对免局灶性脑出血和脑缺血模型血清ＡＣＴＨ、Ｃｏｒ含量变化与脑组织病理改变的相关性研究，以探讨对Ｈ／Ｐ／Ａ功能紊乱的机制。结果显示：脑出血与脑缺血模型急性期血清ＡＣＴＨ、Ｃｏｒ含量水平明显高于恢复期、假手术对照组及正常对照组，以脑出血模型为明显。恢复期时脑缺血模型Ｈ／Ｐ／Ａ功能恢复较差。Ｈ／Ｐ／Ａ功能紊乱程度与脑出血和脑缺血模型后脑组织病理损害程度呈正相关，为脑血管病时Ｈ／Ｐ／Ａ功能紊乱提供了新的理论依据。
In this study, we used radioimmunoassay to study the relationship between changes of ACTH and Cor in serum and the histopathological changes of brain in focal cerebral hemorrhage and cerebral ischemia models to explore the mechanism of H / P / A dysfunction. The results showed that the level of serum ACTH and Cor in acute phase of cerebral hemorrhage and cerebral ischemia model were significantly higher than those in recovery phase, sham operation control group and normal control group. The cerebral hemorrhage model was obvious. Recovery of H / P / A cerebral ischemia model function recovery is poor. The degree of H / P / A dysfunction was positively correlated with the degree of pathological damage of brain tissue after intracerebral hemorrhage and cerebral ischemia, which provided a new theoretical basis for H / P / A dysfunction in cerebrovascular disease.