随着分子生物学的研究与发展,母婴内分泌因子对胎儿生长发育的影响,已受到学者们的广泛关注。其中胰岛素样生长因子(insulin-like growth factor IGF)系统是调控胎儿生长发育最重要的一组分子,并且被认为参与成年期疾病的胎儿期宫内编程。1IGF系统的构成IGF系统包括3个配体(胰 With the research and development of molecular biology, the influence of maternal and child endocrine factors on the growth and development of the fetus has drawn wide attention of scholars. Among them, the insulin-like growth factor (IGF) system is the most important group of molecules that regulate the growth and development of the fetus and is thought to be involved in fetal intrauterine programming of adult diseases. 1 IGF System The IGF system consists of three ligands (Pancreas