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目的了解广州地区2014年登革热NS1抗原阳性与登革热病毒RNA阳性符合率及临床分布,并比较二者的阳性率差异以提高临床诊断准确率。方法收集2014年10月8日至31日广州市第一人民医院疑似登革热患者NS1抗原资料690份和病毒RNA资料315份,并留取其相应的标本检测血清NS1抗原和病毒RNA,统计二者的阳性符合率,利用χ2检验比较二者阳性率的差异。结果 690份检测登革热NS1抗原的患者中有437份NS1抗原阳性,阳性率为63.33%。315份检测登革热病毒RNA的患者有185份登革热病毒RNA阳性,阳性率为58.73%。79例登革热病毒RNA阳性结果中有74例NS1抗原结果阳性,二者阳性符合率为93.67%,其阳性率比较差异无统计学意义(P=0.069)。结论登革热RNA和登革热NS1抗原对于登革热患者的确诊均具有诊断价值,前者相对于后者准确性更高。
Objective To understand the positive coincidence rate and clinical distribution of dengue NS1 antigen and dengue virus RNA in Guangzhou area in 2014, and to compare the positive rates of dengue virus RNA and dengue virus RNA in order to improve the accuracy of clinical diagnosis. METHODS: 690 copies of NS1 antigen and 315 copies of viral RNA were collected from the First People’s Hospital of Guangzhou City from October 8 to 31, 2014. The samples of NS1 antigen and virus RNA were collected for detection of NS1 antigen and virus RNA Positive coincidence rate, usingχ2 test to compare the difference between the two positive rates. Results Among the 690 dengue NS1 antigens, 437 were positive for NS1 antigen, with a positive rate of 63.33%. 185 of dengue virus RNA positive were detected in 315 copies of dengue virus RNA, the positive rate was 58.73%. Of the 79 positive cases of dengue virus RNA, 74 were positive for NS1 antigen, with a positive coincidence rate of 93.67%. There was no significant difference in the positive rate (P = 0.069). Conclusion Dengue fever RNA and dengue NS1 antigen have diagnostic value for the diagnosis of dengue fever, the former is more accurate than the latter.