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为探讨重复肝动脉化疗（TAE）对原发性肝癌（PHC）患者肝脏损伤的影响，对40例经3次TAE治疗的PHC患者和25例肝血管瘤患者（经1次TAE治疗）测定治疗前后透明质酸（HA），层粘连蛋白（LN），人Ⅲ型前胶原（HpcⅢ）和Ⅳ型胶原（Ⅳ·C）的含量。结果发现第2次TAE治疗后，上述4项指标TAE前后均有显著性差异（P＜0．05），以第3次TAE后升高最为明显（P＜0．01）。提示重复TAE治疗常可加重PHC患者的肝损害，应引起足够的重视。
To investigate the effect of repeated hepatic arterial chemotherapy (TAE) on liver injury in patients with primary liver cancer (PHC), 40 patients with PHA treated with 3 TAE and 25 patients with hepatic hemangioma treated with TAE The content of hyaluronic acid (HA), laminin (LN), human type III procollagen (HpcIII) and type IV collagen (IV·C). The results showed that after the second TAE treatment, there was a significant difference before and after TAE (P<0.05), and the increase was most obvious after the third TAE (P<0.01). It is suggested that repeated TAE treatment can aggravate liver damage in PHC patients and should be given enough attention.