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利用多态性DNA片段作为人类遗传性疾病的标记大大扩大了经典连锁分析法的原有作用,并已对人类基因组病理学知识做出了显著的贡献。然而,许多疾病就其遗传方式还不能解释,很明显可能证实有多因子基础。这些疾病可能还是与单基因缺陷研究和诊断的分析技术相一致。本文作者将检测的方式用于DNA多态性的基本原理并特别参考动脉粥样硬化这一复杂疾病的分析作一综述。人群中的0NA多态性“在群体中至少以两种表型存在的孟德
The use of polymorphic DNA fragments as markers of human genetic disorders greatly expands the original role of classical linkage analysis and has made significant contributions to the knowledge of human genomic pathology. However, many diseases can not be explained in terms of their inheritance and it is clear that a multifactorial basis may be confirmed. These diseases may also be consistent with single-gene defect analysis and diagnostic techniques. The authors use the method of detection for the rationale of DNA polymorphism and in particular review the analysis of the complex diseases of atherosclerosis. 0NA polymorphism in the population "Mant’s presence in at least two phenotypes in the population