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目的探讨多西紫杉醇、顺铂、5-氟尿嘧啶的联合化疗方案对进展期胃癌的疗效和毒副作用。方法自2007年1月至2008年12月共有48例进展期胃癌患者入组本次临床研究。化疗方案为:多西紫杉醇75mg/m2,第1天;顺铂25mg/m2,第1～3天;5-氟尿嘧啶500mg/m2,持续滴入或泵入(第1～5天),每3周为1个周期,共2个周期。观察化疗后肿瘤原发病灶的变化情况及化疗的毒副反应。结果临床有效率为62.5%,其中完全缓解(CR)2例,部分缓解(PR)28例,疾病稳定(SD13例),疾病进展(PD)5例。毒副作用主要是白细胞减少、腹泻、恶心、呕吐、脱发,但未有因此而死亡的病例。结论多西紫杉醇加顺铂及5-氟尿嘧啶的联合化疗方案是治疗进展期胃癌有效安全的方法之一。
Objective To investigate the efficacy and side effects of combination chemotherapy of docetaxel, cisplatin and 5-fluorouracil on advanced gastric cancer. Methods A total of 48 patients with advanced gastric cancer from January 2007 to December 2008 were enrolled in this study. Chemotherapy regimens were: docetaxel 75 mg / m2 on day 1; cisplatin 25 mg / m2 on day 1 to 3; and 5-fluorouracil 500 mg / m2 on day 1 to day 5, Week for a cycle, a total of 2 cycles. To observe the changes of the primary tumor after chemotherapy and chemotherapy side effects. Results The clinical effective rate was 62.5%. There were 2 cases of complete remission (CR), 28 cases of partial remission (PR), 13 cases of stable disease (SD) and 5 cases of disease progression (PD). The main side effects are leukopenia, diarrhea, nausea, vomiting, hair loss, but no cases of death. Conclusions Combination chemotherapy of docetaxel plus cisplatin and 5-fluorouracil is one of the effective ways to treat advanced gastric cancer.