Objective To study the efficacy of nimodipine in cognitive rehabilitation of the cerebral infarction.Method (1)Experimental animal models were created in 24 month old Wistar rats,which were treated with nimodipine.Results were compared among the drug treated group,non treated of the same age mice group and 8 month old mice group.(2)Clinical research of nimodipine was conducted in 67 cerebral infarction patients with cognitive impairments.HDS was used as measuring tool.(3)To analyze the related factors such as age,Barthel index and FAQ.Result After 1 month treatment of nimodipine,significant differences between drug dealing and non drug dealing groups were showed in the Y maze discrimination learning experiment(P< 0.05),the duration and errors were improved in drug treated group compared with control group.No significant different result was found in one trial passive avoidance response experiment(P >0.05);single factor analysis(including Barthel index,FAQ and age) did not show significance(P >0.05);there is no statistical differences between nimodipine treated patients and non drug treatment patients(P >0.05).Conclusion Nimodipine showed no efficacy to cognitive rehabilitation in cerebral infarctions. Objective To study the efficacy of nimodipine in cognitive rehabilitation of the cerebral infarction. Method (1) Experimental animal models were created in 24 month old Wistar rats, which were treated with nimodipine. Results were compared among the drug treated group, non treated of the same age mice group and 8 month old mice group. (2) Clinical research of nimodipine was conducted in 67 cerebral infarction patients with Cognitive impairments. HDS was used as measuring tool. (3) To analyze the related factors such as age, Barthel index and FAQ.Result After 1 month treatment of nimodipine, significant differences between drug dealing and non drug dealing groups were showed in Y Maze discrimination learning experiment (P <0.05), the duration and errors were improved in drug treated group compared with control group .No significant different result was found in one trial passive avoidance response experiment (P> 0.05); single factor analysis (including Barthel index, FAQ and age) did not show significance (P> 0.05); there is no statistical differences between nimodipine treated patients and non drug treatment patients (P> 0.05) .Conclusion Nimodipine showed no efficacy to cognitive rehabilitation in cerebral infarctions.