目的：通常情况下，大分子多肽类和蛋白类药物鼻粘膜吸收量很少，故介绍几种提高该类药物经鼻吸收的途径。方法：对近几年来的国内外与鼻粘膜吸收有关的文献进行检索，综述。结果：通过加入吸收促进剂，改变给药剂型，改变药物结构，加入肽酶和蛋白酶抑制剂可提高大分子多肽类和蛋白质药物鼻粘膜给药的生物利用度。结论：通过采取一些措施，大分子多肽类和蛋白类药物的经鼻吸收量可显著提高 Objective: Under normal circumstances, the absorption of macromolecules peptides and protein drugs in the nasal mucosa is very small, so introduce several ways to improve the nasal absorption of these drugs. Methods: To search and summarize the literatures related to nasal mucosa absorption at home and abroad in recent years. RESULTS: The bioavailability of nasal mucosal administration of macromolecular peptides and protein drugs was improved by adding absorption enhancers, changing the dosage form, changing the drug structure and adding peptidase and protease inhibitors. Conclusion: Through some measures, the nasal absorption of macromolecular peptides and protein drugs can be significantly increased