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地方性牙齿氟中毒现象大约55年前第一次发现于坐落在土耳其安纳托利亚西南的Isparta省,该地区氟牙症与饮水中高氟(1.5～4.0mg/L)有关。氟化物来源于火山岩石中的矿物质,包括辉石、角闪石、黑云母、氟磷灰石和玻璃状的矿物石基。据35年前的报道,在Dogubeyazit和Caldiran地区发现人和家畜中严重的牙齿和骨骼氟中毒现象,此地位于土耳其东部的Tendurek火山附近,这里天然水域氟化物含量为2.5～12.5 mg/L。有假说认为从火山喷气口喷出或从析晶火山岩中释放出的氟化物吸附在矿石表面,然后在新生的Tendurek火山山脚和高pH地下水中的OH~-发生交换,从而使氟化物进入水中。地方性牙齿和骨骼氟中毒现象亦发现于土耳其中西部Eskisehir省Beylikova镇Kizilcaoren村的居民中,此地饮水中氟含量为3.9～4.8 mg/L。天然水高氟与此村庄附近蓄水区中氟石沉淀有关。在土耳其中西部南方Esme-Usak的Gullu村视察期间,我们观察到大部分在此村庄出生和生长的10～30岁之间的村民表现出轻度到中度的氟牙症。村中井水氟含量为0.7～2.0 mg/L。Pliocene湖石灰石中微量无定形氟化物可能是此地水域中高氟的一个来源。
Local tooth fluorosis was first detected about 55 years ago in Isparta province, southwestern Anatolia, Turkey, where fluorosis is associated with high levels of fluoride (1.5-4.0 mg / L) in drinking water. Fluoride comes from minerals in volcanic rocks, including pyroxene, amphibole, biotite, fluorapatite and glassy mineral foundations. According to reports 35 years ago, severe dental and skeletal fluorosis was found in humans and livestock in the Dogubeyazit and Caldiran regions, near the Tendurek volcano in eastern Turkey, where natural waters contain fluoride levels of 2.5 to 12.5 mg / L. There is a hypothesis that the fluoride released from the volcanic jet or released from the crystallized volcanics adsorbs to the surface of the ore and then exchanges OH ~ - in the nascent Tendurek volcano and in high pH groundwater to allow fluoride to enter the water . Local tooth and skeletal fluorosis is also found in the residents of Kizilcaoren village in Beylikova town, Eskisehir province, in the central and western Turkey, where the fluorine content in drinking water is 3.9-4.8 mg / L. The high fluoride in natural water is related to the precipitation of fluorite in the impoundment near the village. During the visit to Gullu village in Esme-Usak, south-western Turkey, we observed that the majority of villagers between the ages of 10 and 30 who were born and raised in this village showed mild to moderate dental fluorosis. The village well water fluorine content of 0.7 ~ 2.0 mg / L. Trace amorphous fluoride in the limestone of the Pliocene Lake may be a source of high fluoride in the waters.