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目的:评价注射用鼠神经生长因子(Mouse Nerve Growth Factor for Injection,NGF)在改善神经元特异性烯醇化酶(NSE)测定阳性的宫内发育迟缓(IUGR)患儿预后中的作用。方法:选取2009年1月~2013年12月在该院出生的IUGR患儿,在新生儿娩出时立即抽取脐血,采用ELISA法测定NSE水平,将NSE水平有明显升高的86例IUGR患儿作为研究对象。按家属是否同意使用NGF分为治疗组(46例)和对照组(40例)。两组均进行早期干预及康复治疗,治疗组在此基础上加用NGF 18μg/次,每日1次肌内注射,28天为1疗程,共3个疗程;对照组不使用NGF。新生儿期第28天采用NBNA评分,1岁及2岁时评价两组干预后智力发育指数(MDI)和心理运动发育指数(PDI)。结果:治疗组患儿1岁及2岁时MDI和PDI均高于对照组,差异有统计学意义(P<0.05);治疗组后遗症发生率为4.3%,对照组为17.5%,两组差异有统计学意义(P<0.05)。结论:NSE水平升高是神经损伤的敏感标志物,NGF联合早期干预可促进存在脑损伤的IUGR患儿智力发育,预防并降低神经系统后遗症。
OBJECTIVE: To evaluate the role of Mouse Nerve Growth Factor for Injection (NGF) in improving the prognosis of intrauterine growth retardation (IUGR) patients with positive neuron-specific enolase (NSE). Methods: IUGR infants born in our hospital from January 2009 to December 2013 were enrolled. Umbilical cord blood was collected immediately after the newborn was delivered. NSE levels were measured by ELISA, and 86 IUGR patients with significantly increased NSE levels Children as the research object. According to whether the family members agree to use NGF, they were divided into treatment group (46 cases) and control group (40 cases). Both groups were treated with early intervention and rehabilitation. On the basis of this treatment, the treatment group received NGF 18μg / time, intramuscular injection once a day for 28 days for 1 course of treatment for 3 cycles, while the control group did not use NGF. NBNA score was adopted on the 28th day of neonatal period, and the mental development index (MDI) and psychological motor development index (PDI) after intervention were evaluated at 1 year and 2 years old. Results: The MDI and PDI in the treatment group were significantly higher than those in the control group at 1 year and 2 years (P <0.05). The incidence of sequelae in the treatment group was 4.3% and that in the control group was 17.5% There was statistical significance (P <0.05). CONCLUSIONS: NSE level is a sensitive marker of nerve injury. NGF combined with early intervention may promote the mental development of IUGR children with brain injury and prevent and reduce nervous system sequelae.