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在肿瘤组织中存在着一定量的乏氧细胞,此种细胞增殖缓慢,对抗癌药物敏感性极低,致使化疗效果不好,成为以后复发的根源。本文就高压氧提高肿瘤乏氧细胞的氧饱和度,改善肿瘤细胞增殖状况,增强化疗效果等综述如下。肿瘤内的乏氧细胞英国学者最早发现肿瘤中的慢性乏氧细胞。因受到氧在组织中弥散距离的限制,细胞代谢所需要的氧就会缺乏。在组织中,氧离开血管弥散的最大距离为100～150μm,距离再远,氧张力就接近0,细胞在这种缺氧条件下几小时就会坏死,而在此之间
There is a certain amount of hypoxic cells in the tumor tissue. The proliferation of such cells is slow, and the sensitivity of anticancer drugs is extremely low, resulting in poor efficacy of chemotherapy and becoming the root cause of future relapses. In this paper, hyperbaric oxygen increases the oxygen saturation of tumor hypoxic cells, improves the proliferation of tumor cells, and enhances the effect of chemotherapy. The British scholars of hypoxic cells in tumors first discovered chronic hypoxic cells in tumors. Oxygen required for cell metabolism is lacking due to the restriction of oxygen diffusion distance in the tissue. In tissues, the maximum distance for oxygen to diffuse from the blood vessels is 100 to 150 μm. Further away, the oxygen tension is close to 0. Cells in this kind of hypoxic conditions will be necrotic in a few hours, and in between