目的:探讨急性ST段抬高型心肌梗死(STEMI)患者血浆单体C-反应蛋白(mCRP)水平、整体面积应变(GAS)与冠状动脉(冠脉)病变程度的相关性。方法:选取就诊于我院心内科的180例患者,分为STEMI组150例和对照组30例。其中STEMI组依据Gensini积分分为:轻度组(0<积分≤40)、中度组(40<积分<80)和重度组(积分≥80)。分析血浆mCRP水平及左室射血分数(LVEF)值、GAS值在各组间的差异,Pearson相关分析研究mCRP水平、GAS值与Gensini积分的相关性。结果:(1)STEMI组患者血浆mCRP水平显著高于对照组(P<0.05),STEMI组各亚组间差异亦有统计学意义(P<0.05);STEMI组GAS值低于对照组(P<0.05),各亚组间差异亦有统计学意义(P<0.05)。(2)mCRP水平与Gensini积分正相关(r=0.672,P<0.05),GAS值与Gensini积分呈负相关(r=-0.56,P<0.05)。结论:mCRP水平、GAS与STEMI冠脉病变严重程度密切相关,提示mCRP水平联合GAS可以早期、无创评估STEMI病情严重程度。 Objective: To investigate the correlation between the levels of plasma C-reactive protein (mCRP), global area strain (GAS) and the severity of coronary artery (coronary artery) in patients with acute ST-segment elevation myocardial infarction (STEMI). Methods: A total of 180 patients were enrolled in Department of Cardiology of our hospital. They were divided into STEMI group (150 cases) and control group (30 cases). The STEMI group was divided into mild group (0