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目的 :为了解原发性肾病综合征 (简称肾病 )患儿的血浆脂质变化情况。方法 :观察了 64例肾病患儿的血脂、脂蛋白及载脂蛋白的变化。结果 :肾病患儿血浆总胆固醇 (TC)、甘油三酯 (TG)、低密度脂蛋白胆固醇 (LDL C)、载脂蛋白 (apo)B10 0 以及脂蛋白 (a) [LP(a) ]均明显升高 ,血浆HDL C及apoAI 与对照组比较差异不明显。血浆TC、TG、LDL C、apoB10 0 与血清白蛋白浓度负相关 (P <0 .0 1) ,TC、TG、apoB10 0 、LP(a)与 2 4小时尿蛋白定量无相关。结论 :肾病患儿存在明显脂质紊乱 ,具有动脉粥样硬化、冠心病及进行性肾脏损害的危险因素 ,应加强对肾病高脂血症的随访及防治。
Objective: To understand the changes of plasma lipids in children with primary nephrotic syndrome (referred to as nephropathy). Methods: The changes of blood lipids, lipoproteins and apolipoproteins in 64 children with nephropathy were observed. Results: The levels of total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL C), apolipoprotein B10 0 and lipoprotein (a) [LP Significantly higher plasma HDL C and apoAI compared with the control group was no significant difference. Plasma TC, TG, LDL C and apoB10 0 were negatively correlated with serum albumin concentration (P <0.01). TC, TG, apoB10 0 and LP (a) had no correlation with 24 h urinary protein. Conclusion: There are obvious lipid disorders in children with nephropathy, with atherosclerosis, coronary heart disease and progressive renal damage risk factors, should be to strengthen the follow-up of renal disease and prevention and treatment of hyperlipidemia.