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目的探讨壳聚糖碘治疗宫颈上皮内瘤变Ⅰ(CIN Ⅰ)伴人乳头状瘤病毒(HPV)感染的临床效果。方法选择深圳市南山区西丽人民医院2015年3月-2016年2月收治的CIN Ⅰ伴HPV感染患者176例为研究对象,以随机数字表法分为观察组88例与对照组88例,观察组使用壳聚糖碘治疗,对照组只观察但不接受药物治疗。对两组患者3个月、6个月时的HPV转阴率进行观察。结果观察组随访3个月的HPV转阴率为75.00%,6个月HPV转阴率为86.36%;对照组随访3个月、6个月的HPV转阴率分别为47.73%、65.91%,两组比较差异均有统计学意义(P<0.05);观察组治疗后均未发现严重过敏、发热等全身性不良反应,有1例患者轻微皮肤瘙痒,3天后自然缓解。结论 CIN Ⅰ伴HPV感染治疗中应用壳聚糖碘效果确切,可促进宫颈创面愈合,值得临床推广。
Objective To investigate the clinical effect of chitosan iodine in the treatment of cervical intraepithelial neoplasia Ⅰ (CIN Ⅰ) with human papillomavirus (HPV) infection. Methods A total of 176 patients with CIN Ⅰ with HPV infection admitted to Xili People’s Hospital of Nanshan District, Shenzhen from March 2015 to February 2016 were enrolled in this study. They were divided into observation group (88 cases) and control group (88 cases) by random number table The observation group treated with chitosan iodine, the control group only observed but did not receive drug treatment. Two groups of patients at 3 months, 6 months of HPV negative rate was observed. Results The rate of HPV negative conversion in the observation group was 75.00% at 3 months follow-up, and the negative rate of HPV in 6 months was 86.36%. In the control group, HPV negative conversion rates were 47.73% and 65.91% at 3 months and 6 months respectively, The differences between the two groups were statistically significant (P <0.05). No adverse reactions such as severe allergy and fever were found in the observation group after treatment. One patient had slight skin pruritus and naturally relieved after 3 days. Conclusion CIN Ⅰ with HPV infection in the treatment of chitosan iodine exactly, can promote cervical wound healing, is worth clinical promotion.