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第六节拟肾上腺素药肾上腺素能神经兴奋时,末梢释放去甲肾上腺素。因此从递质分类的角度,拟肾上腺素药应称为拟去甲肾上腺素药。它可以分为三类: 一、主要作用于α受体的兴奋药α受体主要分布在血管、胃肠膀胱括约肌、瞳孔开大肌等处,兴奋时引起该处平滑肌收缩。 1.去甲肾上腺素化学性质不稳定,见光和在碱性溶液中易失效,故不能与碱性药配伍使用。口服不产生吸收作用,皮下注射引起血管剧烈收缩造成组织坏死,一般静脉给药。主要激动α受体,对心脏β_1受体作用很弱,对β_2受体几乎无作用。因此药理作用表现为:① 血
Section 6 adrenergic drugs adrenergic nerve excitations, the release of norepinephrine peripheral. Therefore, from the perspective of neurotransmitters, epinephrine drugs should be called to be norepinephrine drugs. It can be divided into three categories: First, the main role of α-receptor agonists α receptors are mainly located in blood vessels, gastrointestinal sphincter, pupil open big muscle, etc., excited when the smooth muscle contraction caused there. 1. norepinephrine chemical instability, see light and easy to failure in alkaline solution, it can not be used in conjunction with the basic drugs. Oral does not produce absorption, subcutaneous injection caused by severe contraction of blood vessels caused by tissue necrosis, the general intravenous administration. The main agonist alpha receptors, the role of beta 1 receptors on the heart is very weak, almost no effect on beta 2 receptors. Therefore, pharmacological effects as follows: ① blood