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目的 :探讨克罗米芬 (CC)对正常排卵不孕妇女的应用效果。方法 :将 6 2例诊断为不明原因的不孕妇女随机分为两组。自然周期组 31例 ,不接受促排卵药物 ;CC组服用CC ,于月经第 5～ 9天应用 ,每日 5 0mg。随访其排卵及妊娠率。结果 :5例病人因CC的抗雌作用而停用。CC组中周期妊娠率和累计妊娠率均低于自然周期组 ,前者为 7.84%、2 5 .81% ,后者为 2 2 .86 %、5 1.6 1% ,差异均具显著性。宫颈粘液评分和子宫内膜厚度亦低于自然周期组。结论 :CC对于正常排卵妇女无明显增加妊娠率 ,且有一定的副作用 ,应用时应予谨慎。
Objective: To investigate the effect of clomiphene citrate on normal ovulation infertile women. Methods: 62 infertile women diagnosed as unexplained were randomly divided into two groups. The natural cycle group of 31 cases, do not accept ovulation induction drugs; CC group taking CC, menstrual 5-9 days of application, daily 50mg. Followed up their ovulation and pregnancy rates. Results: Five patients were discontinued due to the anti-estrogenic effects of CC. The pregnancy rate and cumulative pregnancy rate in CC group were both lower than those in the natural cycle group, with the former 7.84% and 25.81% and the latter 22.86% and 51.61% respectively. The differences were significant. Cervical mucus score and endometrial thickness were also lower than the natural cycle group. Conclusion: CC for normal ovulation women did not significantly increase the pregnancy rate, and have some side effects, should be used with caution.