1例52岁女性患者因重症再生障碍性贫血行异基因造血干细胞移植术,术后服用环孢素预防移植物抗宿主病。2个月后因肾功能不全,换用他克莫司0.5~1.5 mg,2次/d口服,其血药谷浓度为2.4~7.2μg/L。此后患者逐渐出现气短、疲乏,夜间不能平卧等症状,服用他克莫司50 d后心脏超声检查示室间隔增厚(13 mm)。停用他克莫司,换用西罗莫司和吗替麦考酚酯胶囊后上述症状逐渐好转,20 d后心脏超声检查示室间隔厚度为10 mm。 A 52-year-old female patient underwent allogeneic hematopoietic stem cell transplantation for severe aplastic anemia. Ciclosporin was administered after operation to prevent graft-versus-host disease. Two months later due to renal insufficiency, to switch to tacrolimus 0.5 ~ 1.5 mg, 2 times / d orally, the plasma trough concentration of 2.4 ~ 7.2μg / L. Since then, patients gradually developed shortness of breath, fatigue, and supine at night. After 50 days of tacrolimus echocardiography, ventricular septal thickening (13 mm) was observed. Tacrolimus discontinued, switch to sirolimus and mycophenolate mofetil ester capsules gradually improved after the above symptoms, 20 days after echocardiography showed interventricular septum thickness of 10 mm.