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目的探讨腹腔镜下输卵管妊娠保守手术的同时剥除黄体预防持续性异位妊娠(persistent ectopic pregnancy,PEP)的临床效果。方法采用单中心、前瞻性、随机对照的研究方法,评价239例异位妊娠患者的治疗效果,其中腹腔镜下输卵管妊娠保守手术同时剥除黄体132例为研究组,单纯腹腔镜下输卵管妊娠保守手术107例为对照组。结果研究组PEP发生率0.76%(1/132),对照组为7.48%(8/107),两组差异有统计学意义(P<0.05)。研究组术后β-HCG降至正常所需时间为(10.2±4.2)d,对照组为(14.5±4.8)d,两组差异有统计学意义(P<0.05)。结论腹腔镜下输卵管妊娠保守手术同时剥除黄体是预防PEP的有效方法,其疗效优于单纯腹腔镜下保守手术。
Objective To investigate the clinical efficacy of laparoscopic conservative ectopic pregnancy (PEP) in the treatment of tubal pregnancy with conservative surgery. Methods A single-center, prospective and randomized controlled study was conducted to evaluate the therapeutic effect of 239 patients with ectopic pregnancy. Laparoscopic conservative surgery for tubal pregnancy was performed to remove 132 corpus luteum patients in the study group. Laparoscopic tubal pregnancy was conservative 107 cases of surgery as control group. Results The incidence of PEP was 0.76% (1/132) in the study group and 7.48% (8/107) in the control group, with significant difference between the two groups (P <0.05). The time required for the postoperative β-HCG to decrease to normal in the study group was (10.2 ± 4.2) days, and that in the control group was (14.5 ± 4.8) days. The difference between the two groups was statistically significant (P <0.05). Conclusions Laparoscopic conservative surgery for tubal pregnancy and simultaneous removal of corpus luteum are effective methods to prevent PEP. The curative effect is superior to that of simple laparoscopic conservative surgery.