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中药苦参系豆科植物苦参(Sophora fiavesc-ens Ait)的干燥根,具有多方面的药理作用和临床用途。我们对郯南药厂生产的苦参注射液(含苦参总碱以氧化苦参碱计算不少于10mg/ml)进行了毒性实验研究。一、急性毒性试验在预试验的基础上,选取19～22g健康小鼠50只,雌雄各半。按性别、体重随机分组,均分为五组,每组10只。高低剂量组比值(r)为1:0.75。将各剂量用0.9%氯化钠溶液稀释至0.5ml,尾静脉给药,注射速度为0.1ml/sec。室温20℃±2℃。给药后观察72hr,记录各组动物死亡数。按简化机率单位法统计,测得其半数致死
Traditional Chinese medicine Sophora flavescens is a dry root of Sophora fiavesc-ens Ait. It has many pharmacological effects and clinical applications. We conducted toxicity studies on the flavescens injection produced by Funan Pharmaceutical Co., Ltd. (containing Sophora flavescens total oxymatrine at no less than 10 mg/ml). First, the acute toxicity test Based on the pre-test, select 19 ~ 22g healthy mice 50, male and female. According to gender, weight randomly divided into five groups, 10 in each group. The ratio of high and low doses (r) was 1:0.75. Each dose was diluted to 0.5 ml with 0.9% sodium chloride solution and administered intravenously at an injection rate of 0.1 ml/sec. Room temperature 20 °C ± 2 °C. 72 hours after administration, the number of deaths in each group of animals was recorded. According to the simplified probability unit method, half of the deaths were measured.