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目的:探讨抑郁症患者达临床治愈后突显网络功能连接的变化。方法:选取22名健康对照者（对照组）和17例临床治愈抑郁症患者（临床治愈组）进行静息态功能磁共振成像（resting-state functional magnetic resonance imaging，rs-fMRI）扫描，抑郁症患者在临床治愈基线期以及治愈6个月时分别进行扫描，对rs-fMRI数据进行常规预处理，利用独立成分分析（independent component analysis，ICA）提取突显网络，采用n t检验比较基线期、治愈6个月临床治愈组与对照组的突显网络功能连接差异，并对结果进行AlphaSim校正。n 结果:与对照组相比，基线期临床治愈组背外侧前额叶（n t=2.84）功能连接值增高（n P<0.01，AlphaSim校正）；与基线期相比，治愈6个月的抑郁症患者内侧前额叶（n t=4.08）功能连接值增高，而楔前叶（n t=-3.06）和背外侧前额叶（n t=-2.98）功能连接值减低（n P<0.01，AlphaSim校正）。n 结论:抑郁症患者达临床治愈后突显网络功能连接水平在6个月中并不稳定，基线期临床治愈抑郁症患者突显网络仍存在功能连接异常的脑区，而临床治愈6个月未见突显网络功能连接异常脑区。“,”Objective:To explore the change of salience network functional connectivity over time in patients with clinically cured depression.Methods:Twenty-two healthy controls (control group) and 17 clinically cured depressed patients (clinically cured group) underwent resting-state functional magnetic resonance imaging (rs-fMRI) scan at baseline and 6 months later. Routine preprocessing of rs-fMRI data was performed. Salience network was extracted by independent component analysis (ICA) followed by a n t-test to compare the differences of salience network functional connectivity between the control group and clinically cured patient group at both baseline and 6 months follow-up. Results were corrected by AlphaSim correction method.n Results:At baseline, compared to the control group, clinically cured patient group showed a significantly increased functional connectivity in the dorsolateral prefrontal cortex (n t=2.84, n P<0.01, AlphaSim correction) and a significantly increased functional connectivity in the medial prefrontal cortex (n t=4.08, n P<0.01, AlphaSim correction) as well as a decreased functional connectivity in the left precuneus (n t=-3.06) and dorsolateral prefrontal cortex (n t=-2.98, n P<0.01, AlphaSim correction) at 6 months follow-up.n Conclusion:Patient′s functional connectivity of salience network may not stable during the first 6 months after being clinically cured. The abnormal functional connectivity in the dorsolateral prefrontal cortex when they are initially and clinically cured may gradually improve.