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钙卫蛋白(calprotectin)是近年发现的、与钙结合的、不均一复合蛋白,主要来源于中性粒细胞和单核细胞,分布于粒细胞、上皮细胞及各种组织和体液中,具有抗微生物、调节免疫、抗增殖、传递信号等多种生物学功能,在许多炎症情况下其含量增加。新近的研究显示,钙卫蛋白在炎症性肠病(IBD)患者肠粘膜及粪便中的含量明显高于正常对照者,不仅可以作为评价疾病活动性的指标,而且还可以作为预测疾病复发、评价药物疗效等作用的指标。
Calprotectin is found in recent years, calcium-binding, heterogeneous composite protein, mainly from neutrophils and monocytes, distributed in granulocytes, epithelial cells and various tissues and fluids, with anti- Microorganisms, immune regulation, anti-proliferation, signal transmission and other biological functions, its content increased in many inflammatory conditions. Recent studies have shown that calprotectin in patients with inflammatory bowel disease (IBD) intestinal mucosa and faeces significantly higher than the normal control, not only can be used as an indicator of disease activity, but also can be used as a prediction of disease recurrence, evaluation Drug efficacy and other indicators of action.