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本文主要介绍了黄柏生药袋包颗粒替代饮片汤剂的研究，采用正交试验，以煎出率和盐酸小檗碱含量为指标，优选出黄柏生药袋包颗粒的最佳工艺条件，即粒度为5目，加水量为药材的20倍，煎煮2次，每次15min。在此条件下，测定比较黄柏生药袋包颗粒、饮片、免煎颗粒剂的煎出率，并采用紫外分光光度法，测定比较盐酸小檗碱的含量。其煎出率是饮片的1．14倍、免煎颗粒剂的2倍；其小檗碱含量是饮片的1．27倍、免煎颗粒剂的1．54倍，结果表明5目黄柏生药袋包颗粒为最佳，替代饮片汤剂，方法可行，可节省大量的药材。
This article mainly introduces the study of Huangbai Shengyaobao granules instead of decoction decoction. Orthogonal experiment is used to determine the optimum technological conditions for the pellets of phellodendron edulis, ie, the decocting rate and the content of berberine hydrochloride. 5 heads, 20 times the amount of water for medicinal materials, boiling 2 times, each time 15min. Under this condition, the decoction rates of granules, decoction pieces, and decoction-free granules of Huangbaisheng medicine bag were compared, and the content of berberine hydrochloride was determined by ultraviolet spectrophotometry. Its decoction rate is 1.14 times that of the decoction pieces and 2 times that of the decoction granules; its berberine content is 1.27 times that of the decoction pieces and 1.54 times that of the decoction-free granules. Bao Granules is the best alternative to decoction tablets. The method is feasible and can save a lot of herbs.