最初,5型磷酸二酯酶(PDE5)抑制剂是被批准用于治疗男性勃起功能障碍的,而后又因PDE5抑制剂可能有助于改善内皮细胞功能而被尝试用于治疗某些全身性疾病。但是,自相矛盾的是PDE5可能存在某些威胁患者生命的不良反应。尽管还没有强有力的证据来证实,但是这些不良反应似乎与心血管问题有关,例如心肌梗死以及卒中等。本研究通过评估血清氧化物水平以及对氧磷酶-1的活性,对他达拉非的急性心血 Initially, type 5 phosphodiesterase (PDE5) inhibitors were approved for the treatment of erectile dysfunction in men and were later tried for the treatment of certain systemic diseases because PDE5 inhibitors may help improve endothelial function . Paradoxically, however, PDE5 may have some adverse effects that threaten the lives of patients. Although there is no strong evidence to confirm, but these adverse reactions seem to be related to cardiovascular problems, such as myocardial infarction and stroke. In this study, by assessing serum oxide levels and paraoxonase-1 activity,