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目的 探讨中枢神经系统感染患儿脑脊液中可溶性黏附分子 1 (sICAM 1),白介素 6 (IL 6)的变化。方法 2003年 1~12月河北省儿童医院儿科采用酶联免疫吸附法对 65例中枢神经系统感染患儿在不同时期(急性期、恢复期)的脑脊液进行sICAM 1、IL 6水平的测定,并进行对比分析。结果 急性期化脓性脑膜炎组IL 6、sICAM 1质量浓度均明显高于病毒性脑炎组(P<0 05)及对照组(P<0 05),病毒性脑炎组IL 6、sICAM 1亦高于对照组(P<0 05 )。急性期化脓性脑膜炎组WBC与IL 6及sICAM 1呈显著正相关,相关系数分别为0 799、0 728,IL 6与sICAM 1呈显著正相关,相关系数为 0 939。急性期病毒性脑炎组IL 6与sICAM 1呈显著正相关,相关系数为 0 959。结论 sICAM 1及IL 6参与了中枢神经系统感染的病理生理过程,脑脊液中sICAM 1及IL 6质量浓度可以作为监测中枢神经系统感染性疾病发展状态、判断疾病损害程度的可靠指标。可为化脓性脑膜炎、病毒性脑炎的鉴别诊断提供实验室根据。
Objective To investigate the changes of soluble intercellular adhesion molecule 1 (sICAM 1) and interleukin 6 (IL 6) in cerebrospinal fluid of children with central nervous system infection. Methods From January to December 2003, Pediatric Pediatrics of Children’s Hospital of Hebei Province used enzyme-linked immunosorbent assay to determine the levels of sICAM 1 and IL 6 in cerebrospinal fluid of 65 children with central nervous system infection at different stages (acute stage and convalescent stage) For comparative analysis. Results The concentrations of IL 6 and sICAM 1 in acute purulent meningitis group were significantly higher than those in viral encephalitis group (P <0.05) and control group (P <0 05) Also higher than the control group (P <0 05). There was a significant positive correlation between WBC and IL-6 and sICAM-1 in acute purulent meningitis group, with correlation coefficients of 0 799 and 0 728, respectively. There was a significant positive correlation between IL-6 and sICAM 1, with a correlation coefficient of 0 939. There was a significant positive correlation between IL 6 and sICAM 1 in acute encephalitis group, with a correlation coefficient of 0 959. Conclusions sICAM 1 and IL 6 are involved in the pathophysiological process of CNS infection. The concentrations of sICAM 1 and IL 6 in cerebrospinal fluid can be used as reliable indicators to monitor the development of CNS infectious diseases and determine the degree of disease damage. For purulent meningitis, viral encephalitis to provide laboratory-based differential diagnosis.