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目的:研究中药蓖麻子的抗炎镇痛作用。方法:取蓖麻子炮制品,应用醋酸致小鼠扭体法、小鼠热板法、二甲苯致小鼠耳肿胀法和蛋清致大鼠足跖肿胀法观察其抗炎镇痛作用。结果:蓖麻子炮制品高、中剂量组可减少醋酸致小鼠扭体次数、延长小鼠舔足时间、减轻二甲苯致小鼠耳廓肿胀程度、减轻蛋清致足跖肿胀程度,与空白对照组比较,差异有统计学意义(P<0.01)。结论:中药蓖麻子炮制品具有显著的抗炎镇痛作用。
Objective: To study the anti-inflammatory and analgesic effect of castor bean. Methods: The anti-inflammatory and analgesic effects of castor bean products were observed by the writhing method induced by acetic acid, hot plate method in mice, ear swelling in mice induced by xylene and rat paw edema induced by egg white. Results: Castor oil high and medium dose group can reduce the number of writhing induced by acetic acid in mice, prolong the licking time of mice, reduce the auricle swelling induced by xylene and reduce the degree of paw edema caused by egg white, Group, the difference was statistically significant (P <0.01). Conclusion: Chinese castor bean products have significant anti-inflammatory and analgesic effects.