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目的 :探讨人脑胶质细胞瘤组织内微血管定量 (MVQ)的临床意义。方法 :应用免疫组织化学技术在63例人脑胶质瘤组织中对第Ⅷ因子相关抗原进行表达 ,并计数肿瘤MVQ。结果 :Ⅲ、Ⅳ级胶质瘤MVQ显著高于Ⅰ、Ⅱ级(P<0.05) ;术后18个月内复发和生存期<3年者MVQ分别高于术后18个月无复发及生存期>3年者 (P<0.01) ;MVQ与患者性别、年龄、肿瘤生长部位无明显相关 (P>0.05)。结论 :人脑胶质瘤MVQ与病理分级、术后复发及生存期关系密切 ,可作为一项有意义的预后指标
Objective: To investigate the clinical significance of microvascular volume (MVQ) in human glioma tissue. Methods: Immunohistochemical technique was used to detect the expression of factor Ⅷ related antigen in 63 human glioma tissues, and the tumor MVQ was counted. Results: The MVQ of grade Ⅲ and grade Ⅳ gliomas were significantly higher than those of grade Ⅰ and Ⅱ (P <0.05). MVQ of patients with recurrence and survival less than 3 years after operation within 18 months were higher than those without recurrence and survival after 18 months (P <0.01). There was no significant correlation between MVQ and patient’s gender, age and tumor growth (P> 0.05). Conclusions: MVQ in human glioma is closely related to pathological grade, recurrence and survival, which can be used as a meaningful prognostic indicator