Objective:To determine the suppressive and curative activity of aqueous leaf extract of Ageratum conyzoides(A.conyzoides) in combination with chloroquine and artesunate, respectively against Plasmodium berghei infection in mice.Methods:Using malaria(Plasmodium berghei) infected albino mice of both sexes,aqueous extracts of A.conyzoides in combination with chloroquine and artesunate were tested for antimalarial activity,respectively.Four-day suppressive test and Rane’s curative test were carried out.Results:Suppressive tests showed significant dose dependent reduction in parasitemia level produced by the extract-chloroquine and extract-artesunate combinations.Suppressive activities of both extract-drug combinations were greater than the individual drugs alone.Extract-chloroquine(100:5) produced the highest suppressive effect(98%suppression).Curative tests showed absolute survival in two extract-drug combinations.Two extract-drug combinations produced higher curative effects than the individual drugs alone.The highest dose combinations of extract-chloroquine(100:5) and extract-artesunate(100:5) produced absolute parasitemia clearance(cure) in the infected mice. Conclusions:The study indicated that aqueous extract of A.conyzoides had the ability to potentiate the antimalarial activity of chloroquine and artesunate against induced plasmodiasis in mice.It contributes a lot in the malaria endemic and poverty stricken tropics. Objective: To determine the suppressive and curative activity of aqueous leaf extract of Ageratum conyzoides (A.conyzoides) in combination with chloroquine and artesunate, respectively against Plasmodium berghei infection in mice. Methods: Using malaria (Plasmodium berghei) infected albino mice of both sexes , aqueous extracts of A.conyzoides in combination with chloroquine and artesunate were tested for antimalarial activity, respectively. Focus-day suppressive test and Rane’s curative test were carried out. Results: Suppressive tests showed significant dose dependent reduction in parasitemia level produced by the extract -chloroquine and extract-artesunate combinations. Increasing activities of both extract-drug combinations were greater than the individual drugs alone. Extract-chloroquine (100: 5) produced the highest suppressive effect (98% suppression). Curative tests showed absolute survival in two extract-drug combinations.Two extract-drug combinations produced higher curative effects than the ind ividual drugs alone. The highest dose combinations of extract-chloroquine (100: 5) and extract-artesunate (100: 5) produced absolute parasitemia clearance (cure) in the infected mice. Conclusions: The study indicates that aqueous extract of A.conyzoides had the ability to potentiate the antimalarial activity of chloroquine and artesunate against induced plasmodiasis in mice. It contributes a lot in the malaria endemic and poverty stricken tropics.