目的　探讨微血管密度（ＭＶＤ）检测对判断非小细胞肺癌（ＮＳＣＬＣ） 患者预后的意义。方法　取７１ 例术前未经放疗、化疗的ＮＳＣＬＣ石蜡标本，应用ＦＶⅢ因子相关抗原（ＦＶⅢＡｇ） 抗体免疫组化（ＩＨＣ） 方法标记肿瘤组织内的血管内皮细胞，计算２００ 倍视野下血管最丰富区的ＭＶＤ，即“热点”ＭＶＤ（ｈＭＶＤ） ，另外随机取５ 个２００ 倍视野下血管相对丰富区的ＭＶＤ，计算平均ＭＶＤ（ａＭＶＤ）。统计学采用ｔ 检验和相关系数分析。结果　腺癌的ａＭＶＤ显著高于鳞癌（分别为４１．８±１８ ．６ 及３１．０ ±１２．８，Ｐ＜０．０１），有淋巴结转移的ａＭＶＤ、ｈＭＶＤ 均高于无淋巴结转移的。随着临床分期的进展，ａＭＶＤ的值也逐渐增高。结论　肿瘤血管形成可促进ＮＳＣＬＣ的进展和转移，用ａＭＶＤ 判断患者的预后可能比用ｈＭＶＤ更有意义。 Objective To investigate the significance of detecting microvessel density (MVD) in predicting the prognosis of patients with non-small cell lung cancer (NSCLC). Methods Seventy-one paraffin embedded specimens of NSCLC without radiotherapy and chemotherapy were enrolled in this study. The vascular endothelial cells in the tumor tissue were labeled with FVIII-Ag antibody immunohistochemistry (IHC) MVD in abundant area, namely “hot spot” MVD (hMVD), another randomly selected five 200 times field of MVD vascular relatively rich area, calculate the average MVD (a  MVD). Statistics using t test and correlation coefficient analysis. Results aMVD of adenocarcinoma was significantly higher than that of squamous cell carcinoma (41.8 ± 18.6 and 31.0 ± 12.8, respectively, P <0.01), aMVD with lymph node metastasis and hMVD Higher than without lymph node metastasis. With the progress of clinical staging, a  MVVD values ​​also gradually increased. Conclusion Tumor angiogenesis can promote the progression and metastasis of NSCLC. It is more meaningful to judge the prognosis of patients with aMVD than hMVD.