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目的制备盐酸维拉帕米不溶性微孔膜胶囊剂并研究其体外释药行为。方法以乙酸纤维素(CA)为囊膜材料,聚乙二醇400为增塑剂,蘸胶法制备囊壳,并从致孔剂种类、比例、不同释放条件和内容物配方等因素考察盐酸维拉帕米的释药行为,通过扫描电镜对释药后囊壳结构进行观察。结果选用泊洛沙姆为致孔剂,增加其用量能使药物释放加快;囊内添加柠檬酸,能使药物释放更平稳。结论维拉帕米不溶性微孔膜缓释胶囊在体外能得到缓释效果,通过胶囊内微环境的控制,可以得到平稳的体外释药速度。
Objective To prepare verapamil hydrochloride insoluble microporous membrane capsules and study its in vitro release behavior. Methods Cellulose acetate (CA) was used as the membrane material and polyethylene glycol 400 as the plasticizer. The capsule shell was prepared by dip-coating method. The factors such as the type and proportion of porogen, the different release conditions and the formulation of the contents were investigated. Verapamil release behavior of post-release capsule by scanning electron microscopy was observed. Poloxamers were selected as the porogen and the dosage was increased to accelerate the drug release. The addition of citric acid in the capsule could make the drug release more stable. Conclusion Verapamil insoluble microporous membrane sustained-release capsules can achieve sustained release in vitro, and the sustained release rate in vitro can be obtained by controlling the microenvironment in the capsule.