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[目的]探讨局部持续冲洗化疗在腰椎结核Ⅰ期后路病灶清除植骨融合内固定术中的应用效果.[方法]选择2010年1月至2014年1月本院连续收治的腰椎结核患者55例作为研究对象,其中30例行Ⅰ期后路病灶清除植骨融合内固定术(A组) ,25例行Ⅰ期后路病灶清除植骨融合内固定术联合病灶局部持续冲洗化疗(B组) .比较两组的临床疗效及影像学结果.[结果]所有患者均获随访,随访时间为23 (12～36)个月.两组患者椎间植骨均融合,B组为6 .5 (5～10 )个月较 A 组融合时间8 .5 (6～12)个月明显缩短( P＜0 .05) .术后6周,B组红细胞沉降率(ESR)明显低于A组(P＜0 .05) ,但末次随访时ESR均恢复正常.两组术后神经症状均有不同程度的恢复,伤口均Ⅰ期愈合,无慢性窦道形成,无一例出现内固定断裂,松动等现象.[结论]在Ⅰ期后路病灶清除植骨融合内固定术中联合局部持续冲洗化疗治疗腰椎结核,可以明显加速的植骨融合及炎症的消退,值得临床推广应用.“,”To investigate the effect of local continuous irrigation and chemotherapy on lumbar tuberculosis in stage I posterior debridement ,bone graft fusion and internal fixation .[M ethods]From January 2010 to January 2014 ,55 consecutive patients with lumbar tuberculosis were treated in our hospital .Among them ,30 patients underwent stage I posterior debridement ,bone graft fusion and internal fixation (group A ) , and 25 patients underwent stage I posterior debridement ,bone graft fusion and internal fixation combined with local continuous irrigation and chemotherapy (group B).T he clinical efficacy and imaging results of the two groups were compared .[Results]All patients were followed up for 23 (12～36 ) months .T he intervertebral bone graft fusion time in the group B was 6 .5 (5～10) months ,w hich was significantly shorter than that in the group A [8 .5 (6～12) months] ( P ＜0 .05).Erythrocyte sedimentation rate (ESR) in the group B was signifi‐cantly lower than that in the group A at 6 weeks after operation ( P ＜0 .05) ,but ESR returned to normal at the last follow‐up .T he neurological symptoms of the two groups recovered to varying degrees .T he wounds healed in the first stage .No chronic sinus formation ,internal fixation rupture ,loosening and other phenomena occurred in either group .[Conclusion]T he treatment of lumbar tuberculosis by posterior debridement ,bone graft fusion and internal fixation combined with local continuous irrigation and chemotherapy can significantly accelerate the fusion of bone graft and the regression of inflammation ,w hich is worthy of clinical application .