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目的观察高压氧加神经节苷脂(GM-1)对急性脑梗死认知功能障碍的影响。方法选择90例急性脑梗死认知功能障碍患者随机分为神经节苷脂组、高压氧组与治疗组,每组30例。各组患者均经内科常规治疗,神经节苷脂组、高压氧组分别加用神经节苷脂、高压氧治疗,治疗组在内科规治疗基础上,应用高压氧加神经节苷脂治疗。并于治疗前后行简易智能精神状态检查量表(MMSE)评分及日常生活活动量(ADL)评分。结果治疗组MMSE评分及(ADL)评分改善和另外两组治疗后比较有显著性差异(P<0.05);治疗组治疗前后比较,亦有显著性差异(P<0.01)。结论高压氧加神经节苷脂能明显改善急性脑梗死患者的认知功能及生活质量,且效果优于单纯加用神经节苷脂或者高压氧治疗。
Objective To observe the effects of hyperbaric oxygen plus gangliosides (GM-1) on cognitive dysfunction in acute cerebral infarction. Methods 90 patients with cognitive impairment of acute cerebral infarction were randomly divided into ganglioside group, hyperbaric oxygen group and treatment group, 30 cases in each group. All patients were routinely treated by internal medicine. Ganglioside group and hyperbaric oxygen group were treated with ganglioside and hyperbaric oxygen respectively. The treatment group was treated with hyperbaric oxygen plus ganglioside on the basis of internal medicine treatment. Before and after treatment, the MMSE score and ADL score were taken. Results The improvement of MMSE score and ADL score in the treatment group was significantly different from that in the other two groups (P <0.05). There was also a significant difference between the treatment group before and after treatment (P <0.01). Conclusion Hyperbaric oxygen plus gangliosides can significantly improve cognitive function and quality of life in patients with acute cerebral infarction, and the effect is better than the simple addition of gangliosides or hyperbaric oxygen therapy.