本文用放射免疫方法测定82例老年心脏病患者血清内源性洋地黄样因子(EDF)浓度,结果发现:老年冠心病患者血清EDF浓度明显高于正常(P<0.05);老年慢性肺心病患者血清EDF浓度明显低于正常(P<0.05);老年高血压病患者血清EDF浓度略低于正常,但无显著性差异(P>0.05);合并室性早搏患者血清EDF浓度明显升高(P<0.05);而合并快速房颤患者血清EDF浓度明显降低(P<0.05);血清EDF浓度与心力衰竭严重度呈明显负相关(r=-0.2806,P<0.01);心力衰竭纠正后,血清EDF浓度明显升高(P<0.01)。对老年心脏病患者血清EDF浓度变化的机制与意义进行了讨论。 In this paper, 82 cases of elderly patients with heart disease with endogenous digitalis (EDF) concentrations were determined by radioimmunoassay. The results showed that: EDF concentrations in elderly patients with coronary heart disease were significantly higher than those in normal controls (P <0.05); elderly patients with chronic cor pulmonale Serum EDF concentration was significantly lower than normal (P <0.05); EDF concentration in elderly patients with hypertension was slightly lower than normal, but no significant difference (P> 0.05); EDF concentration in patients with premature ventricular contraction was significantly increased (P (P <0.05). EDF concentrations in serum of patients with AF were significantly lower (P <0.05), serum EDF concentrations were significantly negatively correlated with the severity of heart failure (r = -0.2806, P <0.01) EDF concentration was significantly higher (P <0.01). The mechanism and significance of the change of serum EDF concentration in elderly patients with heart disease were discussed.