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目的：为了解小剂量电离辐射条件下，机体硒的需要量是否有变化，以及补给硒是否有防护电离损伤的效果。方法：用ＳＤ雄性大鼠，喂饲ＡＩＮ７６饲料。予６０Ｃｏ照射，剂量率为４．８６×１０－２Ｇｙ／ｈ，每日照射２小时，每周照射５天，累积剂量为３．６９Ｇｙ。结果：照射组动物体重增长低于不照射组（Ｐ＜０．０５），全血硒含量亦较不照射动物明显减少。每日每鼠补给硒２３μｇ（体重≤３００ｇ）或４５．６μｇ（体重＞３００ｇ）的照射动物体重增长与不照射动物无显著性差异（Ｐ＞０．０５）。补给硒的后期照射与未照射动物之间全血硒的含量未见明显差异。照射后补硒动物的精子畸形率明显低于未补硒的照射动物，并与血硒含量呈明显负相关。结论：在本实验小剂量γ－线照射期间，补给硒对电离辐射损伤有防护作用。
OBJECTIVE: To understand whether there is any change in the demand for selenium and whether selenium is supplied to protect against ionizing damage under the condition of low dose ionizing radiation. Methods: SD male rats were fed AIN76 diet. To 60Co irradiation, the dose rate of 4.86 × 10-2Gy / h, 2 hours a day, 5 days a week irradiation, the cumulative dose of 3.69Gy. Results: The body weight gain of irradiation group was lower than that of non-irradiation group (P <0.05), and the content of selenium in whole blood was also significantly decreased compared with non-irradiation group. There was no significant difference (P> 0.05) between the body weight gain and the non-irradiated animals fed 23μg selenium (body weight ≤300g) or 45.6μg (body weight> 300g) daily. There was no significant difference in the content of selenium in whole blood between late irradiation and non-irradiation animals supplying selenium. The sperm deformity of selenium-enriched animals after irradiation was significantly lower than those of non-selenium-exposed animals, and was negatively correlated with the blood selenium content. CONCLUSIONS: Selenium supplementation has a protective effect against ionizing radiation injury during the low dose γ-ray irradiation in this experiment.