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目的探讨恶性综合征的临床特点与治疗,提高临床工作者对本综合征的认识。方法对18例NMS患者进行临床评价。结果①18例患者均有肌强直、高热、意识障碍、肌酸激酶值增高②发病3d内确诊并及时治疗者10例,全部存活,1周内未得到确诊者2例,全部死亡。结论NMS以肌强直、发热、意识障碍、肌酸激酶值增高为主要特征。避免误诊、早诊断早治疗是提高生存率的关键所在。
Objective To investigate the clinical features and treatment of malignant syndrome and to improve clinicians’ understanding of this syndrome. Methods 18 cases of NMS patients were evaluated. Results ①There were myotonia, fever, disturbance of consciousness and creatine kinase in all 18 patients. ② 10 patients were diagnosed and promptly treated within 3 days of onset. All survived. Two patients were not diagnosed in one week and all died. Conclusion NMS is characterized by muscle rigidity, fever, disturbance of consciousness and increased creatine kinase. Avoid misdiagnosis, early diagnosis and early treatment is the key to improve the survival rate.