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近年来急性心肌梗塞多数是因为心肌广泛坏死而发生泵衰竭死亡。因之,保护心肌可以改善急性心肌梗塞之发展。关于 GIK 和强地松龙对缺血性心肌之保护作用虽有些报告,但对各药物之效果仍有争议。而 GIK 与氢化可地松联合治疗几乎没有报导。我们用10支杂种狗进行实验研究,以结扎左前降支冠状动脉闭塞10分钟,测量缺血区(ischemic zone)和交界区(border zone)之心肌间质 K~+浓度,并以血液动力学为指标,如心搏出量、血压和左室舒张末期压(LVEP)监测。用药组于冠状动脉结扎前一小时静滴 GIK(葡萄糖40克、胰岛素12单位、钾10毫当
In recent years, most of acute myocardial infarction is due to extensive myocardial necrosis and pump failure death. Therefore, protecting the myocardium can improve the development of acute myocardial infarction. Although some reports on the protective effects of GIK and prednisolone on ischemic myocardium, the effects on each drug are still controversial. GIK and hydrocortisone combined treatment is almost never reported. We used 10 mongrel dogs to carry out experimental studies to ligate the left anterior descending coronary artery for 10 minutes and measure the myocardial interstitial K ~ + concentrations in the ischemic zone and border zone. The hemodynamics As indicators, such as cardiac output, blood pressure and left ventricular end-diastolic pressure (LVEP) monitoring. The medication group was given intravenous GIK one hour before coronary artery ligation (40 g of glucose, 12 units of insulin and 10 ml of potassium