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临床上使用的一些合(氯)霉素溶液处方中,常采用不等量的硼砂、硼酸、氯化钠等作缓冲剂或稳定剂。我们从实际操作中发现硼砂对合(氯)霉素具有一定的助溶作用。为了满足临床上有较高的治疗浓度的合(氯)霉素液的需要,我们用硼砂对合霉素进行了水中增溶试验。其方法就是选用不同比例的合霉素与硼砂溶解在一定量的蒸馏水中作溶解度试验;并经过一个月的观察。结果表明:以合霉素:硼砂在2:1的情况下,可将合霉素在水中的溶解度从0.25％提高到9％。为了考虑到因硼砂含量浓度过高、碱性增強,可能影
Clinically used in some of the (chlorine) mildew solution prescription, often using different amounts of borax, boric acid, sodium chloride as a buffer or stabilizer. We found from the actual operation of borax (Co) chlorine has a certain role in co-dissolving. In order to meet the clinical need for higher therapeutic concentrations of (chloramphenicol) solution, we performed in-water solubilization assay for tetracycline using borax. The method is to use different proportions of tetracycline and borax dissolved in a certain amount of distilled water for solubility test; and after a month of observation. The results showed that the solubility of chlortetracycline in water could be increased from 0.25% to 9% with chlortetracycline: borax at 2: 1. In order to take into account the borax concentration is too high, alkaline enhanced, may shadow