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目的探讨氯吡格雷联合前列地尔治疗急性脑梗死的临床疗效。方法选取2012年1月—2015年1月解放军第159中心医院收治的急性脑梗死患者82例,根据治疗方式分为对照组与观察组,各41例。对照组予以氯吡格雷治疗。观察组在对照组基础上加用前列地尔治疗,比较两组患者临床疗效、神经功能缺损(NIHSS)评分及不良发应发生情况。结果观察组患者总用效率高于对照组,差异有统计学意义(P<0.05);治疗前两组患者NIHSS评分比较,差异无统计学意义(P>0.05),治疗后观察组NIHSS评分低于对照组,差异有统计学意义(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论氯吡格雷联合前列地尔治疗急性脑梗死的临床疗效显著,可有效改善神经功能。
Objective To investigate the clinical effect of clopidogrel and alprostadil in the treatment of acute cerebral infarction. Methods 82 patients with acute cerebral infarction admitted to the 159th Central Hospital of PLA from January 2012 to January 2015 were divided into control group and observation group, 41 cases in each group. The control group was treated with clopidogrel. The observation group was treated with alprostadil on the basis of the control group, and the clinical efficacy, NIHSS score and incidence of adverse reactions were compared between the two groups. Results The total effective rate of observation group was higher than that of control group, the difference was statistically significant (P <0.05). There was no significant difference in NIHSS score between the two groups before treatment (P> 0.05) In the control group, the difference was statistically significant (P <0.05). Two groups of patients with adverse reactions, the difference was not statistically significant (P> 0.05). Conclusion Clopidogrel combined with alprostadil is effective in treating acute cerebral infarction. It can effectively improve neurological function.