Poisson-Nest-Planck equations are widely used to describe the electrodiffusion of ions in a solvated biomolecular system.Two kinds of two-grid finite element algorithms are proposed to decouple the steady-state Poisson-Nest-Planck equations by coarse grid finite element approximations.Both theoretical analysis and numerical experiments show the efficiency and effectiveness of the two-grid algorithms for solving Poisson-Nest-Planck equations.