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目的通过对梯度回波序列法与平面回波(echoplanerimaging,EPI)序列法重建脑膜瘤相对血流量图的比较,对脑膜瘤相对血流量的定量检测进行评价。方法应用西门子1.5TMR仪对18例脑膜瘤病人进行检查,获取常规的T1WI、T2WI和增强T1WI,以及动态的磁顺应敏感图像(T2WI梯度回波序列或SEEPI序列)。在采集动态的磁顺应敏感图像期间(梯度回波法12例,EPI法6例),应用程控注射器以每秒5ml的流率注入钆喷替酸葡甲胺(GdDTPA)(0.2mmol/kg)。应用优视系统(advancedvisualsystem,AVS)软件逐点处理动态的磁顺应敏感资料,对重建的全部相对血流量图作感兴趣区分析,通过借鉴文献中脑灰质血流量数值,定量计算脑膜瘤的相对血流量。结果肿瘤相对血流量与脑灰质相对血流量的比率是3.01±1.18(梯度回波序列法为3.07±1.39;EPI序列法为2.84±0.94)。脑膜瘤的平均相对血流量为(14.47±5.96)ml/100g:梯度回波序列法为(14.85±6.72)ml/100g,EPI序列法为(13.72±4.54)ml/100g;梯度回波序列法与EPI序列法的结果比较差异无统计学意义(t=0.42,P=0.68)。结论应用脑灰质血流量数值法可便捷地定量检测脑膜瘤的相对血流量,脑膜瘤的相对血流量明显增高而且非均匀性;血脑屏障破坏情况下,仍可估算相对血流量值;尽管EPI序列法更具有效应,梯度回波序列法和EPI序列法均能有效地应用于相对血流量的测定。
OBJECTIVE: To evaluate the relative quantification of meningioma in patients with meningiomas by comparing the relative blood flow of meningiomas with gradient echo sequence and echoplanerimaging (EPI). Methods Totally 18 cases of meningioma were examined by Siemens 1.5TMR instrument. The conventional T1WI, T2WI and T1WI enhancement and dynamic MRS (T2WI gradient echo sequence or SEEPI sequence) were obtained. GdDTPA (0.2 mmol / kg) was injected into the program-controlled syringe at a flow rate of 5 ml per second during the acquisition of a dynamic magnetic resonance-sensitive image (gradient echo method in 12 cases and EPI method in 6 cases) . Using advanced visual system (AVS) software to process dynamic MRS data point by point, the ROI of all the reconstructed CT images was analyzed. The relative meningiomas were calculated by using the values of gray blood flow in the literature Blood flow. Results The ratio of tumor relative blood flow to gray matter relative blood flow was 3.01 ± 1.18 (gradient echo sequence method was 3.07 ± 1.39; EPI sequence method was 2.84 ± 0.94). The mean relative blood flow of meningiomas was (14.47 ± 5.96) ml / 100g, with a gradient echo sequence method of (14.85 ± 6.72) ml / 100g and EPI sequence method of (13.72 ± 4.54) ml / There was no significant difference between the EPI and the EPI (t = 0.42, P = 0.68). Conclusions The relative blood flow of meningiomas can be quantitatively and conveniently detected by using the numerical method of cerebral gray blood flow. The relative blood flow of meningioma is obviously increased and inhomogeneous. In the case of blood-brain barrier failure, the relative blood flow can still be estimated. EPI sequence method is more effective, gradient echo sequence method and EPI sequence method can be effectively applied to the determination of relative blood flow.