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我们采用半定量多重聚合酶链反应（ＰＣＲ）和ＰＣＲ单链构象多态性（ＳＳＣＰ）检测了４８例慢性粒细胞白血病（ＣＭＬ）患者ｐ１６基因纯合缺失和点突变，以期从分子生物学水平探讨ｐ１６基因分子生物学异常与ＣＭＬ的关系。对象和方法１ 对象 １２名正常人，男性７名，?
We used a semi-quantitative multiplex polymerase chain reaction (PCR) and PCR-single strand conformation polymorphism (SSCP) to detect homozygous deletions and point mutations in the p16 gene in 48 patients with chronic myelogenous leukemia (CML), in hopes from molecular biology. To explore the relationship between abnormal molecular biology of p16 gene and CML. Subjects and Methods 1 Subjects 12 normal subjects, 7 males,?