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目的 探讨血清中CYFRA 2 1-1、CA 15 -3水平的检测对乳腺癌术后监测价值。方法 随访 2 85例乳腺癌术后患者 ,复发转移 5 6例。采用放射免疫法定期检测患者血清中CYFRA 2 1-1、CA15 -3水平。结果 CYFRA2 1-1、CA15 -3检测阳性率远处转移者高于局部复发者 ;2种标志物联合检测阳性率高于单个标志物检测阳性率。复发转移患者中 18例完全缓解者治疗后CYFRA 2 1-1、CA 15 -3检测值及阳性率较治疗前显著下降 ;7例患者CYFRA 2 1-1、CA15 -3联合检测阳性结果时间较临床确诊时间早 3周～ 9个月。结论 定期检测乳腺癌术后患者血清CYFRA 2 1-1、CA 15 -3水平 ,对监测其肿瘤复发转移及判断疗效方面有重要价值 ,2种标志物的联合检测优于单个标志物检测。
Objective To investigate the serum levels of CYFRA 2 1-1 and CA 15 -3 in postoperative monitoring of breast cancer. Methods A total of 2 85 cases of breast cancer patients were followed up and 56 cases were recurred. Serum levels of CYFRA 2 1-1 and CA15 -3 were measured by radioimmunoassay. Results The positive rates of CYFRA2 1-1 and CA15 -3 in patients with distant metastasis were higher than those with local recurrence. The positive rates of the combined detection of two markers were higher than those of single markers. The detection value and positive rate of CYFRA 2 1-1 and CA 15 -3 in 18 patients with complete remission after treatment were significantly lower than those before treatment. The positive results of CYFRA 2 1-1 and CA15 -3 in 7 patients were significantly lower than those before treatment Clinical diagnosis of early 3 weeks to 9 months. Conclusion Regular detection of serum levels of CYFRA 2 1-1 and CA 15 -3 in postoperative patients with breast cancer is of great value in monitoring the recurrence and metastasis of the tumor and in judging the therapeutic effect. The combined detection of two markers is superior to single marker detection.