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药理作用:本品为组胺 H_2 受体拮抗剂,对胃及十二指肠溃疡的治疗具有高效,其作用比甲氰咪胍(Cimetidine)约强4～5倍,且具有速效和长效的特点,能有效地抑制组胺及胃泌素刺激后的胃酸分泌,使胃酸减少和胃蛋白酶活性降低。单次口服80mg 后30～90分钟,血清峰值浓度平均为165μg/L,抑制氢离子50%。口服后有效时间可维持12小时,胃肠道吸收迅速.不受食物如抗酸剂的影响。生物利用度口服为静脉注射的50%。半衰期约为2～2.5小时。大部分药物以原型从肾脏排泄少量被代谢为
Pharmacological effects: This product is a histamine H 2 receptor antagonist, the treatment of gastric and duodenal ulcers with high efficiency, its role than cimetidine (Cimetidine) about 4 to 5 times stronger, and has a quick and long-acting Of the characteristics, can effectively inhibit the histamine and gastrin stimulation of gastric acid secretion, so that reduced gastric acid and pepsin activity decreased. After a single oral dose of 80mg 30 ~ 90 minutes, the average serum concentration of 165μg / L, 50% inhibition of hydrogen ions. Effective time after oral administration can be maintained for 12 hours, rapid absorption of the gastrointestinal tract. Not affected by food such as antacids. Bioavailability was 50% orally administered intravenously. Half-life is about 2 ~ 2.5 hours. Most drugs are metabolized to a small amount by the prototype excretion from the kidneys