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目的观察盐酸特比萘酚阴道泡腾片治疗外阴阴道假丝酵母菌病(VVC)的有效性、安全性及其短期内复发情况。方法将133例VVC患者随机分组,观察组(A组)应用盐酸特比萘酚阴道泡腾片治疗,对照组1(B组)应用硝酸咪康唑栓,对照组2(C组)应用硝呋太尔制霉素阴道软胶囊治疗。A,B两组用药时间均为7d,C组用药时间为14d。结果 (1)停药3~4d复查临床有效率为100%(A组),93.5%(B组)和80.0%(C组),病原体转阴率为100%(A组),91.3%(B组)和80.0%(C组),A组的临床有效率和病原体转阴率均高于B组和C组,差异具有统计学意义(P均<0.05)。(2)停药后首次月经干净3~7d内复查的临床有效率为95.8%(A组),86.9%(B组)和77.5%(C组),病原体转阴率分别为95.7%,84.8%,77.5%,A组和B组的临床有效率和病原体转阴率差异无统计学意义(P均>0.05)。A组和C组比较,差异具有统计学意义(P均<0.05)。(3)3组患者均无药物相关不良反应。结论盐酸特比萘酚阴道泡腾片治疗VVC疗效确切、安全性好,并且短期复发率低。
Objective To observe the efficacy, safety and short-term recurrence of terbinafine hydrochloride vaginal effervescent tablets in the treatment of vulvovaginal candidiasis (VVC). Methods A total of 133 VVC patients were randomly divided into observation group (group A) treated with terbinafine hydrochloride vaginal effervescent tablets, control group 1 (group B) with miconazole nitrate suppository, and control group 2 (group C) Alginicillin vaginal soft capsule treatment. A, B two groups were treated for 7d, C group medication for 14d. Results (1) The clinical effective rates were 100% (group A), 93.5% (group B) and 80.0% (group C) after discontinuation for 3 ~ 4 days. The negative rate of pathogens was 100% (group A), 91.3% B group) and 80.0% (C group). The clinical effective rate and the negative rate of pathogens in group A were higher than those in group B and C (P <0.05). (2) The clinical effective rates of the first menstruation after the withdrawal were 95.8% (group A), 86.9% (group B) and 77.5% (group C) within 3 to 7 days after stopping the treatment. The negative rates of pathogens were 95.7% and 84.8 %, 77.5% respectively. There was no significant difference in clinical efficacy and pathogen negative conversion rate between group A and group B (all P> 0.05). The difference between group A and group C was statistically significant (all P <0.05). (3) There were no drug-related adverse reactions in the 3 groups. Conclusion Terbinafine hydrochloride vaginal effervescent tablets in the treatment of VVC is effective, safe and short-term recurrence rate.