论文部分内容阅读
目的 :探讨内镜下卢戈氏液染色法在普查食管早期癌的应用。方法 :按要求普查 2 5 7例。先在内镜下观察食管粘膜有无异常后 ,用 1.2 %卢戈氏液涂布染色 ,对呈现碘染色或碘不染色的不同案例 ,分别做指示性活检送病理检查。并观察分析内镜所见、碘染色有无与活检病理的关系。结果 :内镜下正常 ,碘染色正常 ,活检正常率占 6 7.32 % ,而碘不染例中多为食管慢性炎和不典型增生 ,活检正常率占 2 8.2 9% ,较前者明显低 (P <0 .0 1)。内镜下异常且碘染例中 ,查出鳞癌 2例 ,不典型增生 2 2例 ,食管慢性炎等 81例 (39.5 1% )。后者同碘染色正常 10例 (19.2 3% )比较 ,有显著性差异 (P <0 .0 5 )。 2例重度不典型增生 ,均在碘不染例中发现。结论 :卢戈氏液染色法可提高食管早期癌及不典型增生的发现率 ,值得在临检和普查中应用
Objective: To investigate the application of Lugol’s solution staining under endoscopy in census esophageal early cancer. Methods: A total of 257 cases were screened as required. After observing whether the esophageal mucosa had abnormalities under the endoscope, 1.2% Lugol’s solution was used for coating and staining. For the cases with iodine staining or iodine-free staining, instructive biopsy was performed for pathological examination. Observe and analyze the relationship between iodine staining and biopsy pathology. Results: Under endoscopy, normal iodine staining, normal rate of biopsy accounted for 63.32%, and most of the iodine-free cases were esophageal chronic inflammation and atypical hyperplasia. The normal rate of biopsy was 28.19%, which was significantly lower than the former (P). <0. 0 1). Endoscopic abnormalities and iodine cases, found in 2 cases of squamous cell carcinoma, atypical hyperplasia in 22 cases, esophageal chronic inflammation in 81 cases (39.5 1%). The latter was compared with normal iodine staining in 10 cases (19.2 3%), with significant difference (P < 0.05). Two cases of severe dysplasia were found in iodine-free cases. Conclusion: Lugol’s staining method can improve the detection rate of early esophageal cancer and atypical hyperplasia, and is worthy of being used in clinical examination and census.