我院位于海拔 2 2 60ｍ的高海拔地区 ,气候寒冷、干燥、风沙大。呼吸系统疾病发病率较高 ,常并发急、慢性呼吸衰竭 ,机械通气是其关键的急救手段。呼吸机相关性肺炎 (ＶＡＰ)是急、慢性呼吸衰竭患者机械通气治疗过程中常见并发症和重要的致死原因 ,其病原菌多为难治性 ,并对抗 Our hospital is located at an altitude of 2 2 60m high altitude area, the climate is cold, dry, large sandstorm. The incidence of respiratory diseases is high, often complicated by urgency, chronic respiratory failure, mechanical ventilation is its key first aid. Ventilator-associated pneumonia (VAP) is a common complication and an important cause of death during mechanical ventilation in patients with acute and chronic respiratory failure. Most of the pathogens are refractory and resistant