目的：探讨ＮＯＳ抑制剂ＬＮＡＭＥ（左旋硝基精氨酸甲酯）对沙土鼠海马区环磷酸鸟苷（ｃＧＭＰ）的影响。方法：钳夹沙土鼠的双侧颈总动脉制造脑缺血模型，应用免疫荧光法染色，以便观察ｃＧＭＰ浓度的变化及分布。结果：ＬＮＡＭＥ抑制ｃＧＭＰ的合成。结论：ＬＮＡＭＥ是一氧化氮合酶（ＮＯＳ）强有力的抑制剂，抑制了ＮＯ及其介导的ｃＧＭＰ的合成 Objective: To investigate the effect of NOS inhibitor LNAME (L-NAME) on cyclic guanosine monophosphate (cGMP) in gerbil hippocampus. Methods: The bilateral common carotid arteries of the gerbils were used to make the model of cerebral ischemia. The immunofluorescence staining was used to observe the changes and distribution of cGMP concentration. RESULTS: LNAME inhibited the synthesis of cGMP. CONCLUSION: LNAME is a potent inhibitor of nitric oxide synthase (NOS) and inhibits the synthesis of NO and its cGMP