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消炎痛是非甾体类抗炎镇痛药,由于口服后常引起胃肠道不良反应,所以消炎痛栓剂给药日益被人们所重视。我国1985年版药典已将消炎痛栓剂列为法定制剂。中空栓剂是国外近年来正在研究的一种新型栓剂,因为这种栓剂的空腔内药物能以粉末或液体的状态存在,所以即可避免胃肠道反应和首过效应,又能快速地发挥药理作用。本文制备了消炎痛的中空栓剂,并对这种栓剂的体外溶出度及兔体内生物利用度进行了研究。
Indomethacin is a non-steroidal anti-inflammatory analgesic. Since oral administration often causes gastrointestinal adverse reactions, administration of indomethacin suppository is increasingly valued. China’s 1985 edition Pharmacopoeia has indomethacin suppository as a statutory agent. Hollow suppository is a new type of suppository under study abroad in recent years. Because the drug in the cavity of this suppository can exist in the state of powder or liquid, it can avoid the gastrointestinal reaction and the first pass effect, and can quickly exert Pharmacological effects. In this paper, hollow suppositories of indomethacin were prepared, and the in vitro dissolution rate of this suppository and bioavailability in rabbits were studied.