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十多年来,一些学者研究了人及动物NK细胞的性质.越来越多的迹象表明NK细胞有多种功能:包括对肿瘤,对病毒、对其他微生物感染、对骨髓移植的天然抵抗力.现就NK细胞的形态学、NK与K细胞的关系、NK细胞的细胞毒机理、NK细胞的调节作用、NK细胞与肿瘤及感染等的关系分别加以讨论.一、NK细胞的特征Santoli等(1979)从单个核细胞组分中除去粘附的及吞噬细胞,发现增强了细胞毒活性,并发现细胞毒组分富含于带有IgGFc受体的细胞而不含于具有IgMFc受
For more than a decade, some scholars have studied the properties of human and animal NK cells, and there is a growing body of evidence that NK cells have multiple functions including tumor, viral infection, infection with other microorganisms, and natural resistance to bone marrow transplantation We will discuss the relationship between the morphology of NK cells, the relationship between NK and K cells, the cytotoxic mechanism of NK cells, the regulation of NK cells, the relationship between NK cells and tumors and infections, etc. 1. Characteristics of NK Cells Santoli et al. (1979) removed adherent and phagocytic cells from mononuclear cell fractions and found to enhance cytotoxic activity and found that cytotoxic components are enriched in cells bearing IgGFc receptors and not in cells with IgMFc receptors