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目的:建立姜胆咳喘片的微生物限度检查方法。方法:参照《中国药典》2005年版,采用5种阳性对照菌回收率试验测定其是否含抑菌成分。结果:该品种对金黄色葡萄球菌和枯草芽孢杆菌有抑菌活性,采用离心沉淀集菌和培养基稀释联用的方法进行细菌数的测定,采用常规法进行霉菌和酵母菌数的测定及控制菌的检查。结论:用该法进行微生物限度检查,可以客观地反映药物中微生物的污染状况,可行性强,能达到检测目的。
Objective: To establish a method of checking the limits of microorganisms in Jiang gall e asthma tablets. Methods: According to “Chinese Pharmacopoeia” 2005 edition, using five kinds of positive control bacteria recovery test to determine whether it contains antibacterial ingredients. Results: The strain had antibacterial activity against Staphylococcus aureus and Bacillus subtilis. The bacteria count was determined by centrifugal sedimentation and culture medium dilution. The number of molds and yeasts was determined and controlled by the conventional method Check the bacteria. Conclusion: The method of microbial limit test can objectively reflect the microbial contamination in the drug, feasibility is strong, can achieve the purpose of testing.