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目的:分析γ-氨基丁酸联合常规雾化吸入治疗对哮喘患者血清学指标和诱导痰指标的影响。方法:选取在本院接受治疗的哮喘患者116例纳入研究,对治疗方案及化验结果进行回顾性分析后,所有入组患者被分为观察组(n=60)、对照组(n=56)。对比两组血清及诱导痰中病情相关因子及蛋白表达情况差异。结果:观察组治疗后血清PDGF-BB、SP、LTE4、CGRP水平低于对照组,TGFβ1水平高于对照组,差异具有统计学意义(P<0.05);观察组高于对照组,差异具有统计学意义(P<0.05);观察组治疗后诱导痰SCF、M-CSF、CKLF1、ICAM-1水平低于对照组,差异具有统计学意义(P<0.05);观察组治疗后诱导痰MCP-1、Gal-3、RAGE、HMGB1、SDF-1水平均低于对照组,差异具有统计学意义(P<0.05)。结论:哮喘患者接受γ-氨基丁酸联合常规雾化吸入治疗,血清及诱导痰病情严重程度相关指标水平均得到优化,对于疾病治疗及预后转化等均有积极意义。
Objective: To analyze the effects of γ-aminobutyric acid combined with conventional inhalation therapy on serum and sputum indexes in patients with asthma. Methods: One hundred and sixteen patients with asthma admitted to our hospital were enrolled in the study. After retrospective analysis of treatment regimen and test results, all patients were divided into observation group (n = 60), control group (n = 56) . The differences of the related factors and protein expression between the two groups of serum and induced sputum were compared. Results: The levels of PDGF-BB, SP, LTE4 and CGRP in the observation group were lower than those in the control group, and the levels of TGFβ1 were higher in the observation group than in the control group (P <0.05); the observation group was higher than the control group (P <0.05). The levels of SCF, M-CSF, CKLF1 and ICAM-1 in the induced sputum in the observation group were lower than those in the control group (P <0.05) 1, Gal-3, RAGE, HMGB1 and SDF-1 in the control group were significantly lower than those in the control group (P <0.05). CONCLUSIONS: Asthmatic patients receiving γ-aminobutyric acid combined with conventional inhalation therapy have been optimized for serum and sputum induced severity of disease severity and are of positive significance for disease treatment and prognosis.